Primary outcomes
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Peripheral blood
Complete blood counts
(12+ blood parameters critical for MPN).
Changes in allele burden across relevant cell populations
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Bone marrow
Comprehensive characterization of bone marrow composition and JAK2-V617F allele burden.
Grading of bone marrow fibrosis by histopathology
Spleen
Assessment of splenomegaly and alterations of extramedullary hematopoiesis within the spleen
Generation of a cohort with the required phenotype: PV, ET or MF
Our customizable experimental design
Drug treatment according to the chosen regimen
Analyses of peripheral blood, bone marrow, spleen and more
in vivo drug studies
Evaluate the efficacy of your drugs in our mouse models of Myeloproliferative Neoplasms
Cytokine profiling
Pharmacokinetics
Histopathology
RNA-sequencing
Our Streamlined Workflow
Initial Consultation
Tell us about your specific needs, and we will identify the best way to assist you. We will work closely with you to understand your objectives and tailor our services to meet your requirements.
Project Design
We customize our robust and well-established experimental setups to align with the specific objectives and unique requirements of your project. This ensures our approach is precisely suited to your research goals.
Protocol Execution
Our experienced team rigorously performs every procedure and ensures that animal welfare is upheld throughout the process.
Data Analysis
We provide a thorough and comprehensive analysis of multiple parameters relevant to Myeloproliferative Neoplasms, delivering detailed insights to support your research.
Strategic Recommendations
Drawing on our extensive experience with MPN preclinical models, we offer expert advice on the significance of the results and recommend potential follow-up experiments to advance your research further.